activity modification
Treatment for Cluster Headache
Psilocybin acts as a potent 5-HT2A receptor agonist, which modulates serotonergic neurotransmission and may interrupt cluster headache pathophysiology through central nervous system mechanisms. Its potential therapeutic effect in cluster headache is hypothesized to involve neuroplastic changes and disruption of the trigeminovascular pain pathway, potentially reducing headache frequency and intensity through altered neural processing.