Amphetamines act as potent central nervous system stimulants that increase dopaminergic and noradrenergic neurotransmission, potentially disrupting pain signaling pathways in cluster headache. Their sympathomimetic properties and ability to modulate neural excitability may help interrupt the trigeminal-autonomic reflex and reduce the frequency and intensity of cluster headache attacks. When used under medical supervision, these medications can provide prophylactic or abortive therapeutic benefits for patients with treatment-resistant cluster headaches.