analgesic
Treatment for Cluster Headache
Sumatriptan, a selective serotonin receptor (5-HT1B/1D) agonist, rapidly constricts cranial blood vessels and inhibits pro-inflammatory neuropeptide release in the trigeminal system. When administered subcutaneously or intranasally, it provides rapid relief from acute cluster headache symptoms by reducing neurogenic inflammation and alleviating severe pain through central and peripheral mechanisms.