anesthetic
Treatment for Cluster Headache
Ketamine, an NMDA receptor antagonist, acts as a dissociative anesthetic that can rapidly modulate neuronal excitability and interrupt pain signaling pathways in cluster headache treatment. When administered in sub-anesthetic doses, it provides potent analgesic and anti-inflammatory effects by blocking glutamate-mediated neuronal transmission and reducing central sensitization. Its unique pharmacological profile allows for quick interruption of pain cycles and potential neuroplastic reset in cluster headache pathophysiology.