Lucent Patient

anticonvulsants

Treatment for Cluster Headache

Anticonvulsants like topiramate and valproate modulate neuronal excitability by enhancing GABA-mediated inhibition and reducing glutamate-mediated excitation, thereby stabilizing neuronal membranes and suppressing abnormal neuronal firing associated with cluster headache pathogenesis. These medications reduce neurogenic inflammation, decrease neuronal hyperexcitability, and modify pain signal transmission in the trigeminal system, ultimately decreasing the frequency and intensity of cluster headache episodes.

3.5

AVERAGE EFFICACY

CASE STUDIES

REDDIT COMMENTS

124

REPORTED SIDE EFFECTS

Case Studies

Cited By ...

4.0

Two patients with refractory cluster headache (one chronic, one episodic) who had failed standard therapies experienced marked reduction in attack frequency and intensity when treated with levetiracetam. The treatment was well tolerated and led to significant clinical improvement.

anticonvulsants

Two cases of cluster headache effectively treated with levetiracetam

5.0

Two patients with episodic cluster headache refractory to verapamil, lithium, and topiramate achieved complete and sustained remission of attacks when treated prophylactically with levetiracetam.

anticonvulsants

Cluster-Tic or Tic-Cluster? Trigeminal Neuralgia (Tic) Turning to Trigeminal Autonomic Cephalalgia (TAC) Following Venous Decompression of the Trigeminal Nerve: A Case Report and Review of the Literature

3.0

A 75-year-old man initially presented with trigeminal neuralgia that resolved after venous decompression surgery, but then developed cluster headaches two years later, representing a rare case of sequential "Tic-cluster" syndrome.

anticonvulsantsinjectionsurgeryindomethacincorticosteroid

Cluster-status migrainosus with a weekly periodicity responsive to high-flow oxygen: A case report

4.0

A 54-year-old female presented with a unique pattern of cluster headaches that evolved into status migrainosus, which was successfully treated with high-flow 100% oxygen after multiple other treatments failed.

beta blockersvalproateantiepilepticsamitriptylinegabapentinanticonvulsantstriptansbutalbitaloxygen therapy

Reddit Comments

INeed-M-O-N-E-Y

4.0

Lithium worked temporarily for me. After I tried lamotrigine, which has worked for the last 7 years (presumably)

Anticonvulsants

Miserable-Ninja2066

5.0

I have both also. Lamotrigine got rid of CH and I was chronic for years. Had to switch to lithium temporarily and that worked too. Now I'm on depakote. I did get a brief relapse in CH a couple weeks ago but then when I did blood work to check depakot...View more

AnticonvulsantsLithiumValproate

Reported Side Effects

None

Miserable-Ninja2066

5.0

I was at point where I couldn't get much lower.Yes I saw quick results with lamotrigine. Depression was still there a bit but headaches were gone. My Dr switched from lithium because the depression was still prevalent and lithium is an older drug.

Anticonvulsants

No-Night6738

4.0

Just read a post by someone who seems to have gotten his CH under control with Lamotrigine. So definitely worth discussing with your doctor as you may be able to kill two birds with one stone.

Anticonvulsants

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