antiemetics
Treatment for Cluster Headache
Antiemetics used in Cluster Headache management, such as metoclopramide and ondansetron, primarily act as 5-HT3 receptor antagonists or dopamine receptor blockers to inhibit the chemoreceptor trigger zone (CTZ) in the brain. These medications suppress nausea and vomiting while potentially providing additional symptomatic relief by modulating neurotransmitter pathways associated with headache pathogenesis.