Lucent Patient

antiepileptics

Treatment for Cluster Headache

Antiepileptic drugs like topiramate and valproate modulate neuronal excitability by enhancing GABA-mediated inhibition and blocking voltage-gated sodium and calcium channels, which reduces neurogenic inflammation and suppresses abnormal neuronal firing patterns associated with cluster headaches. These medications can decrease the frequency and intensity of cluster headache attacks by stabilizing neuronal membranes and attenuating pain signal transmission in the trigeminovascular system.

3.4

AVERAGE EFFICACY

CASE STUDIES

2195

REDDIT COMMENTS

4064

REPORTED SIDE EFFECTS

Case Studies

Behandlung eines atypischen und therapierefraktären Clusterkopfschmerzes mit Topiramat

4.0

A patient with atypical and refractory cluster headache unresponsive to standard acute therapies, corticosteroids, and verapamil experienced prompt and marked pain relief after starting topiramate.

antiepilepticstriptanscorticosteroidcalcium channel blockers

[Remission of atypical and refractory cluster headache after topiramate administration].

4.0

A single patient with cluster headache, unresponsive to standard acute and prophylactic therapies, achieved pain relief only after administration of topiramate.

headache medicationcorticosteroidcalcium channel blockersantiepileptics

Chronic Cluster Headache with a Pediatric Onset: The First Japanese Case Report

4.0

This report describes the first Japanese pediatric-onset chronic cluster headache case in a 9-year-old girl whose attack frequency and severity were markedly reduced using verapamil and lomerizine prophylaxis and oral sumatriptan abortively.

calcium channel blockerslomerizineantiepilepticstriptansoxygen therapy

Effective Treatment of Refractory Cluster Headache With Propranolol

5.0

A 22-year-old male with refractory cluster headache unresponsive to verapamil, eletriptan, topiramate, and occipital nerve blocks experienced complete and sustained relief after introduction of low-dose propranolol.

antiepileptics

Reddit Comments

Punk_Rock_Kid

3.0

## Migraines + Clusters? Can you or do you have both at the same time? I’ve had migraines since I was like 8 (32F) and they were almost always right side unilateral. Around 18, I noticed they started moving left side more often, going only directly...View more

Antiepileptics

Reported Side Effects

None

Comradekels_

4.0

## Migraine or Cluster- opinions? Hi- I have suffered migraines for years since a TBI, tension headaches, aura, not aura, ocular, you name it. Nothing has worked to help (botox, triptans, amitriptaline, monthly shot, magnesium) other than topamax (a...View more

AntiepilepticsGepantHeat therapy

Revlovelution

4.0

I'm sorry that you're here. I've read some good things here. First, careful with the sumatriptan, don't know if you got the injections but taking more than two a day for more than ten days will get you even more headaches. Getting frustrated d...View more

TriptansOxygen therapyCalcium channel blockersAntiepilepticsLithiumVitamin dCaffeineCorticosteroid

Reported Side Effects

Rebound headache

unbambinospeciale

4.0

40M here. I've had both since I was 3. Got almost completely rid of migraines with daily THC treatment. Still have chronic CH though; I'm treating it with sumatriptan injections and high flow oxygen. Please, please, please, if you're doing topiramat...View more

CannabisTriptansOxygen therapyAntiepileptics

Reported Side Effects

Kidney damage

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