Antioxidants such as melatonin and vitamin E are investigated in cluster headache management for their ability to neutralize reactive oxygen species and reduce oxidative stress in neural tissues. By scavenging free radicals and modulating mitochondrial function, these compounds may help mitigate neurogenic inflammation and potentially interrupt the pathological cascade associated with cluster headache pathogenesis. Their neuroprotective properties suggest potential prophylactic benefits in reducing headache frequency and severity.