azelastine
Treatment for Cluster Headache
Azelastine is a potent, non-sedating dual histamine H1 receptor antagonist and mast cell stabilizer that may provide relief in cluster headache by reducing neurogenic inflammation and modulating pain signaling pathways. Its mechanism involves blocking histamine receptors and inhibiting the release of pro-inflammatory mediators, which can potentially interrupt the neurogenic processes associated with cluster headache pathogenesis.