botulinum toxin
Treatment for Cluster Headache
Botulinum toxin, when used for Cluster Headache, acts by blocking acetylcholine release at neuromuscular junctions and inhibiting pain-related neuropeptide transmission. This leads to reduced neurogenic inflammation and decreased sensitization of trigeminal nerve pathways, potentially interrupting the pathophysiological mechanisms underlying cluster headache pain. By modulating neural signaling, botulinum toxin can provide prophylactic relief and decrease the frequency and intensity of cluster headache episodes.