Caffeine cessation in Cluster Headache management involves withdrawal from the sympathomimetic agent that acts as an adenosine receptor antagonist, potentially disrupting neurovascular and neuroinflammatory pathways. Abrupt discontinuation can lead to rebound vasodilation and altered cerebral blood flow, which may trigger or exacerbate cluster headache episodes. The cessation process requires careful medical supervision to mitigate potential neurological and vascular complications associated with sudden caffeine withdrawal.