caffeine modification
Treatment for Cluster Headache
Caffeine acts as a non-selective adenosine receptor antagonist, blocking A1 and A2A receptors and inhibiting adenosine-mediated vasodilation. In cluster headache treatment, it can potentially constrict cerebral blood vessels and modulate neurotransmitter release, which may help reduce headache intensity and frequency by counteracting vasodilatory mechanisms associated with the condition.