Cannabis, particularly strains high in THC and CBD, may modulate pain perception and neuroinflammation in cluster headaches through interaction with CB1 and CB2 cannabinoid receptors in the central nervous system. Its potential therapeutic effects include reducing pain intensity, decreasing inflammatory responses, and potentially interrupting the neurovascular mechanisms underlying cluster headache pathogenesis. The analgesic and neuroprotective properties of cannabinoids suggest a potential role in managing the severe pain and autonomic symptoms associated with this condition.