Capsicum, primarily through its active compound capsaicin, acts as a potent transient receptor potential vanilloid 1 (TRPV1) agonist that desensitizes nociceptive neurons and modulates pain transmission. When applied topically or nasally, it can interrupt neurogenic inflammation and provide analgesic effects by depleting substance P and reducing pain signal transmission in trigeminal nerve pathways. Its mechanism is particularly beneficial in cluster headache management by potentially interrupting the neurological cascade that triggers these intense cephalalgic episodes.