Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that reduces inflammatory prostaglandin synthesis by specifically targeting the COX-2 enzyme. In cluster headache treatment, it may help modulate neurogenic inflammation and provide analgesic effects, potentially mitigating pain and inflammatory processes associated with the condition. However, its primary role in cluster headache management is not as a first-line treatment, and its efficacy is less established compared to other interventions.