Clomid (clomiphene citrate) is a selective estrogen receptor modulator (SERM) that may potentially disrupt the hypothalamic-pituitary-gonadal axis and alter neurotransmitter dynamics, which could theoretically influence cluster headache pathogenesis. While not a primary treatment for cluster headaches, some clinicians have observed its potential to modulate neurological pain signaling and potentially reduce headache frequency through hormonal and neurochemical interactions.