combination analgesic
Treatment for Cluster Headache
A combination analgesic for cluster headache typically includes a rapid-acting triptan (such as sumatriptan) and a non-steroidal anti-inflammatory drug (NSAID) like naproxen. Sumatriptan acts as a selective serotonin receptor agonist that constricts cranial blood vessels and inhibits pro-inflammatory neuropeptide release, while naproxen provides additional pain relief through cyclooxygenase (COX) enzyme inhibition, reducing inflammatory mediators and peripheral pain signaling.