Sumatriptan/Zolmitriptan combined with oxygen therapy provides rapid relief for cluster headaches by selectively targeting 5-HT1B/1D receptors to cause vasoconstriction and inhibit neuropeptide release, while supplemental oxygen reduces cerebral blood flow and alleviates pain. The combination leverages the triptan's neurogenic anti-inflammatory effects and direct vascular action with oxygen's vasoconstrictive properties to effectively interrupt the acute pain cascade of cluster headaches.