Oxygen therapy and sumatriptan are primary comfort interventions for Cluster Headache, with oxygen acting as a cerebral vasoconstrictive agent that reduces intracranial blood flow and alleviates pain through rapid inhalation at high flow rates. Sumatriptan, a selective 5-HT1B/1D receptor agonist, works by causing vasoconstriction in cranial blood vessels and inhibiting pro-inflammatory neuropeptide release, effectively interrupting the neurogenic inflammation associated with Cluster Headache attacks.