Contraceptives, when used for Cluster Headache treatment, typically involve hormonal mechanisms that modulate neurotransmitter and endocrine pathways to potentially reduce headache frequency and intensity. By altering hormonal fluctuations and providing a more stable neurochemical environment, these medications may help mitigate the inflammatory and vascular changes associated with cluster headache pathogenesis. The primary effects include reducing neurogenic inflammation and stabilizing cerebrovascular reactivity.