Cooling therapy for Cluster Headache involves the application of cold stimuli, typically through intranasal or facial cooling devices, which triggers a trigeminal-autonomic reflex that can interrupt and modulate pain signaling. The cold stimulus causes vasoconstriction and reduces local nerve conductivity, potentially suppressing the hypothalamic and trigeminal nerve hyperactivity associated with Cluster Headache pathogenesis. This non-pharmacological intervention provides rapid pain relief by altering neural signaling and inflammatory responses in the trigeminovascular system.