Creatine acts as a neuroprotective and energy substrate enhancer in cluster headache management, potentially modulating mitochondrial energy metabolism and reducing neuronal oxidative stress. By increasing phosphocreatine levels in neural tissues, it may help stabilize cellular energy dynamics and reduce neuroinflammatory processes associated with cluster headache pathogenesis. The supplementation appears to support mitochondrial function and potentially mitigate neuronal energy deficits that may contribute to headache onset and severity.