Curcumin, a polyphenolic compound from turmeric, exhibits potent anti-inflammatory and antioxidant properties that may help mitigate neurogenic inflammation and oxidative stress associated with cluster headaches. Its primary mechanism involves inhibiting pro-inflammatory cytokines and NF-κB pathways, potentially reducing neurogenic inflammation and providing neuroprotective effects that could modulate pain perception and vascular responsiveness in cluster headache pathogenesis.