Cyclobenzaprine is a centrally-acting muscle relaxant with tricyclic chemical structure that may modulate pain perception and neural signaling in cluster headache management. It primarily works by reducing muscle tension and potentially influencing serotonin and norepinephrine neurotransmission in the central nervous system, which can help mitigate pain and provide symptomatic relief. However, its direct efficacy specifically for cluster headaches is not definitively established, and its use is often considered off-label.