Lucent Patient

cyproheptadine

Treatment for Cluster Headache

Cyproheptadine is a first-generation antihistamine with antiserotonergic properties that acts as an antagonist at 5-HT2A and 5-HT2C receptors, potentially modulating serotonergic neurotransmission implicated in cluster headache pathogenesis. By blocking these serotonin receptors, it may help reduce the frequency and intensity of cluster headache attacks, though its precise mechanism in this context is not fully elucidated.

2.7

AVERAGE EFFICACY

CASE STUDIES

REDDIT COMMENTS

REPORTED SIDE EFFECTS

Case Studies

No case studies available.

Reddit Comments

Ziah70

4.0

i gained a bunch of weight from managing my migraines and i am so glad I did. i took cyproheptadine for two ish years and it worked wonders, but i finally stopped it a month or so ago and my migraines have not come back. Managing my migraines made me...View more

Cyproheptadine

Reported Side Effects

Weight gain

karate134

4.0

Periactin is great for adults too... It's only really limited by the weight gain that really hits adults (and sedation) There's some other great ones: -memantime (namenda) which is similar to magnesium as it works on NMDA receptors, which pretty mu...View more

Cyproheptadine

Reported Side Effects

Weight gainDrowsiness

Ct412007

4.0

Cyproheptadine as a preventative has been a huge help for me. I’ve tried just about every other med listed on this sub except for Botox injections and Vyepti, which is the next course of action if the CH stops working. Topamax was the only other prev...View more

CyproheptadineSumatriptan

Reported Side Effects

General side effect

Hot-Alternative-7367

5.0

I’m in Australia and my neurologist suggested trialling both periactin and long acting Naproxen. I believe both are OTC medications, but I got a script from the neuro. Worked a treat to tie me over until I could take my Ajovy. The Periactin is to be ...View more

CyproheptadineNaproxenFremanezumab

Reported Side Effects

Drowsiness