A dental appliance for cluster headache typically involves an oral splint or positioning device that helps modulate trigeminal nerve activity and reduce sympathetic nervous system stimulation. By altering mandibular and cranial positioning, the appliance can potentially decrease parasympathetic nerve irritation and reduce vascular inflammation associated with cluster headache pathogenesis. The mechanism aims to interrupt neurogenic pain signaling pathways and provide mechanical intervention to mitigate headache severity and frequency.