Divalproex, a valproic acid derivative, is believed to modulate neuronal excitability by enhancing GABA-mediated inhibition and blocking voltage-gated sodium channels in cluster headache management. Its mechanism reduces neuronal hyperexcitability and stabilizes neuronal membranes, potentially decreasing the frequency and intensity of cluster headache episodes. While not a first-line treatment, it can be effective in prophylactic management of these severe headache disorders.