Dimethyl sulfoxide (DMSO) acts as a potent vasodilator and neuroprotective agent when used for Cluster Headache, potentially disrupting aberrant neurovascular signaling in the trigeminal-autonomic pathway. By modulating neurogenic inflammation and membrane permeability, DMSO may reduce pain transmission and vascular reactivity, offering symptomatic relief through its unique pharmacological properties. Its ability to cross biological membranes and interact with neural and vascular tissues makes it a promising therapeutic intervention for this severe neurological condition.