epinephrine
Treatment for Cluster Headache
Epinephrine acts as a potent α and β-adrenergic agonist that can rapidly constrict cerebral blood vessels and reduce neurogenic inflammation during cluster headache attacks. By stimulating α1 receptors, it causes vasoconstriction and reduces intracranial blood flow, while β2 receptor activation can help modulate neural pain transmission and provide rapid symptomatic relief.