Epsom salt, composed of magnesium sulfate, may provide relief in cluster headaches by potentially modulating neuronal excitability and reducing inflammation through magnesium's inhibitory effects on N-methyl-D-aspartate (NMDA) receptors. Its topical or systemic administration can help counteract magnesium deficiency, which is associated with increased neurogenic inflammation and pain sensitivity, potentially mitigating the intensity and frequency of cluster headache episodes.