ergonomic modifications
Treatment for Cluster Headache
Ergotamine is a potent vasoconstrictor that acts on serotonin and dopamine receptors, effectively reducing cerebral blood vessel dilation and alleviating pain in cluster headaches. By binding to 5-HT1B/1D receptors in cerebral vasculature, it rapidly constricts blood vessels and interrupts the neurogenic inflammatory cascade associated with cluster headache pathophysiology. Its quick onset and targeted mechanism make it a preferred treatment for acute cluster headache episodes.