ergotamine caffeine
Treatment for Cluster Headache
Ergotamine caffeine is a vasoconstrictor combination that acts on serotonin receptors and causes cranial blood vessel constriction, effectively reducing cerebral blood flow and alleviating cluster headache symptoms. The ergotamine component primarily targets 5-HT1B/1D receptors, while caffeine enhances the drug's absorption and provides additional vasoconstrictive effects, making it particularly effective in treating acute cluster headache episodes.