Exercise, when used as a management strategy for Cluster Headache, acts through complex neurophysiological mechanisms involving endorphin release, modulation of autonomic nervous system activity, and reduction of inflammatory markers. The primary effects include decreased sympathetic tone, increased pain threshold, and potential neuroplastic changes that may help regulate the hypothalamic dysfunction associated with Cluster Headache pathogenesis. Regular aerobic exercise can potentially reduce headache frequency and intensity by promoting neurochemical balance and improving overall autonomic nervous system regulation.