Lucent Patient

gepant

Treatment for Cluster Headache

Gepants are CGRP receptor antagonists that block calcitonin gene-related peptide (CGRP) signaling, which plays a critical role in cluster headache pathogenesis. By inhibiting CGRP receptors, gepants can potentially reduce neurogenic inflammation and pain transmission associated with cluster headache attacks, offering a targeted therapeutic approach with fewer systemic side effects compared to traditional treatments.

3.2

AVERAGE EFFICACY

CASE STUDIES

REDDIT COMMENTS

REPORTED SIDE EFFECTS

Case Studies

No case studies available.

Reddit Comments

Comradekels_

4.0

## Migraine or Cluster- opinions? Hi- I have suffered migraines for years since a TBI, tension headaches, aura, not aura, ocular, you name it. Nothing has worked to help (botox, triptans, amitriptaline, monthly shot, magnesium) other than topamax (a...View more

AntiepilepticsGepantHeat therapy

AccomplishedDust974

3.0

Try CGRPs (ubrelvy, zavzpret), Botox, im on nortriptyline to help every day migraines and it has helped and ubrelvy to stop a migraine and have used both CGRPs mentioned above for a cluster attack. It worked 1/2x

GepantTricyclic antidepressants

Purple_twilight

3.0

I'm pretty new to CH but have been using the cold red bull, they gave me imitrex, but in pill form and no more than 9 per month. My pcp put me on Nurtec as it is an abortive (dissolves under your tongue) and preventive. I have noticed some differenc...View more

CaffeineTriptansGepant

Hot_Tangerine1699

2.0

Lately she’s been having pain most of the day, at a 2/10 or 3/10 and then she feels the pains go up to a 5-7. She got Nurtec yesterday and taking ibuprofen. It’s not helping all that much. We’re thinking it’s histamine/ gut related. Her BP has been ...View more

GepantNsaids

Reported Side Effects

HeadacheHypertension

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