Ginger supplementation may help mitigate cluster headache symptoms through its potent anti-inflammatory properties, primarily mediated by gingerols and shogaols that inhibit pro-inflammatory cytokines and cyclooxygenase (COX) enzymes. These compounds potentially reduce neurogenic inflammation and modulate pain signaling pathways, offering a natural alternative for managing the intense pain associated with cluster headaches by decreasing vascular inflammation and neurological sensitization.