Guanfacine is an alpha-2A adrenergic receptor agonist that acts centrally to reduce sympathetic nervous system activity and modulate noradrenergic signaling. While primarily used for ADHD and hypertension, its potential application in Cluster Headache involves reducing neurogenic inflammation and modulating pain perception through central nervous system sympathetic downregulation. Limited clinical evidence suggests it may help mitigate the frequency and intensity of cluster headache episodes by altering neurovascular mechanisms.