Homeopathic remedies for cluster headaches typically involve highly diluted substances like Sanguinaria, Spigelia, or Bryonia, which are selected based on specific symptom patterns. Despite the extreme dilution that precludes molecular presence, homeopathy suggests these preparations interact with the body's vital energy, potentially modulating neurogenic inflammation and pain perception through unknown quantum or energetic mechanisms. Clinical evidence for efficacy remains limited, with most scientific consensus viewing homeopathic interventions as placebos.