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indomethacin

Treatment for Cluster Headache

Indomethacin is a potent non-selective cyclooxygenase (COX) inhibitor that reduces prostaglandin synthesis, effectively alleviating inflammation and pain. In cluster headache treatment, it acts by suppressing neurogenic inflammation and modulating pain perception, with its primary therapeutic effect being the interruption of the inflammatory cascade and subsequent pain reduction.

4.2

AVERAGE EFFICACY

CASE STUDIES

223

REDDIT COMMENTS

270

REPORTED SIDE EFFECTS

Case Studies

A case of remitting hemicrania continua with seasonal variation and clustering: a diagnostic confusion with cluster headache

5.0

A 36-year-old man with episodic strictly unilateral headaches that mimicked cluster headache but in fact represented remitting hemicrania continua failed to respond to standard cluster headache therapies and had a complete response to indomethacin.

indomethacin

Cluster headache responsive to indomethacin: Case reports and a critical review of the literature

5.0

Four patients with cluster headache, some refractory to standard therapies, showed complete remission of attacks after treatment with high-dose indomethacin over one to two weeks, challenging the notion that cluster headache never responds to indomethacin.

indomethacinoxygen therapycalcium channel blockerslithium

O004. Refractory chronic cluster headache responding absolutely to indomethacin

5.0

A 72-year-old man with refractory chronic cluster headache, unresponsive to sumatriptan and oxygen, experienced prompt and complete relief of attacks with intramuscular indomethacin and sustained remission on oral indomethacin prophylaxis.

indomethacin

[PDF] Cluster headache responsive to indomethacin: Case reports and a critical review of the literature | Semantic Scholar

4.0

This case study reports four patients with cluster headache who responded to indomethacin treatment, challenging the conventional view that cluster headache is unresponsive to indomethacin.

indomethacin

Reddit Comments

Wise-Fig-6505

3.0

The easiest way to buy pure oxygen is to go on Amazon and order a few canisters of Boost oxygen, the kind athletes use. At least you can try it out. You might also try a drug called indomethacin. If your CH is at all caused by inflammation, it might ...View more

Oxygen therapyIndomethacin

Girl_Anachronism07

4.0

Those oxygen cans are useless. But I second an indomethacin trial. My neuro recently told me indo working has nothing to do with inflammation, which I’m still flabbergasted over.

Indomethacin

Reported Side Effects

General side effect

Girl_Anachronism07

4.0

Paroxysmal Hemicrania is in the TAC family but is known to respond to indomethacin, an anti-inflammatory. It’s also tagged as a shorter duration, which below you mention they last about 20 minutes. I went through a similar experience where an uninfor...View more

Indomethacin

Reported Side Effects

Kidney dysfunction

Emotional-Ocelot

2.0

Temporary stuff that works for some people includes ice, cold, heat , exercise, caffeine and taurine. Clusterbusters is a good place to look. That said, when I say 'works' it might help, a little bit, sometimes. But you'll probably still be having...View more

Cold therapyHeat therapyExerciseCaffeineTaurineIndomethacinNaproxen

Reported Side Effects

General side effect

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