kratom
Treatment for Cluster Headache
Kratom (Mitragyna speciosa) contains alkaloids like mitragynine and 7-hydroxymitragynine that act as partial μ-opioid receptor agonists and interact with adrenergic and serotonergic systems, potentially providing analgesic and vasoconstrictive effects beneficial for cluster headache management. Its unique pharmacological profile may help interrupt or reduce the intensity of cluster headache episodes through modulation of neurotransmitter systems and pain perception pathways.