Lemon balm (Melissa officinalis) may modulate cluster headache symptoms through its GABAergic properties and potential inhibition of glutamate release, which can reduce neuronal hyperexcitability. Its active compounds, including rosmarinic acid and essential oils, exhibit mild sedative and anxiolytic effects that may help mitigate the intense pain and autonomic symptoms associated with cluster headaches by promoting neurological relaxation and potentially reducing inflammatory responses.