Lisdexamfetamine is a central nervous system stimulant that acts as a prodrug for dextroamphetamine, which enhances dopaminergic and noradrenergic neurotransmission in the brain. While not a first-line treatment for Cluster Headache, it may potentially modulate pain perception and neurological pathways through its sympathomimetic properties and ability to alter neurotransmitter dynamics. Its use in Cluster Headache is considered off-label and requires careful medical supervision due to potential side effects and addiction risks.