Lomerizine is a calcium channel blocker that specifically inhibits voltage-dependent L-type calcium channels, reducing neuronal calcium influx and modulating neurotransmitter release. In cluster headache management, it helps prevent cerebrovascular and neurogenic inflammation by decreasing calcium-mediated neuronal excitability and potentially reducing vascular smooth muscle contractility. Its mechanism leads to decreased pain signal transmission and vasodilation, which may contribute to its prophylactic efficacy in cluster headache treatment.