Manual therapy for Cluster Headache involves targeted manipulation of cervical and cranial structures to modulate neurological pain pathways and autonomic nervous system activity. By applying specific techniques that stimulate mechanoreceptors and proprioceptive nerve endings, manual therapy can potentially reduce sympathetic nervous system hyperactivity and interrupt the trigeminal-autonomic reflex associated with cluster headache pathogenesis. The primary effects include decreased muscle tension, improved neurological regulation, and potential reduction in pain intensity and frequency.