Triptans, like sumatriptan, are selective serotonin receptor (5-HT1B/1D) agonists that cause vasoconstriction of cranial blood vessels and inhibit neurogenic inflammation. When used for cluster headache, they rapidly abort acute attacks by modulating serotonergic neurotransmission and reducing pain signal transmission in the trigeminal system. These medications provide quick relief by directly targeting the pathophysiological mechanisms underlying cluster headache.