Lucent Patient

methylfolate

Treatment for Cluster Headache

Methylfolate is a bioactive form of folate that can potentially reduce cluster headache frequency by modulating methylation processes and homocysteine metabolism. By supporting neurotransmitter synthesis and reducing oxidative stress, methylfolate may help mitigate neurological inflammation and improve vascular endothelial function, which can contribute to cluster headache prophylaxis.

2.4

AVERAGE EFFICACY

CASE STUDIES

REDDIT COMMENTS

REPORTED SIDE EFFECTS

Case Studies

No case studies available.

Reddit Comments

threedragoncircus

3.0

I take this too! I started taking l-methyfolate, which I think means it's 'activated' folic acid? I don't really know the difference. But having insufficient folic acid can change how well your body absorbs nutrients and medications, especially (or m...View more

Methylfolate

Reported Side Effects

General side effect

Suckerforcats

1.0

Are you treating it? I only have the one gene and was prescribed l-methylfolate for it for awhile and didn’t notice any difference. It wasn’t covered by insurance because it’s considered a food so it was kind of expensive.

Methylfolate

Reported Side Effects

General side effect

None

4.0

I have a gene issue on one of the L-methyltetrahydrofolate reductase (MTHFR) genes. I get bad reactions to triptans, and no relief from most pain medications. Taking L-Methylfolate supplements has improved my quality of life. It's the methylated vers...View more

Methylfolate

Reported Side Effects

General side effect

bluefran1977

4.0

Really good responses so far! OP I’m in late 40s and peri-M too. I have chronic migraines that were very bad a few years ago so I made a lot of lifestyle changes. I resigned my senior (well paid) but stressful job and now work freelance. I drink alco...View more

Nerve blockErenumabAtogepantHormone replacement therapyMagnesiumMethylfolateSeleniumZincOmega-3Vitamin dVitamin kProbioticsGuar gum

Reported Side Effects

General side effect