midodrine
Treatment for Cluster Headache
Midodrine is an alpha-1 adrenergic agonist that selectively activates postsynaptic alpha-1 receptors, causing vasoconstriction and increased blood pressure. In the context of Cluster Headache, it may help modulate vascular tone and potentially reduce the intensity and frequency of neurovascular pain by counteracting vasodilation and improving cerebral perfusion dynamics.