motion sickness medication
Treatment for Cluster Headache
Dihydroergotamine (DHE) is a vasoactive ergot alkaloid that acts as a potent vasoconstrictor and serotonin receptor agonist, specifically targeting 5-HT1B and 5-HT1D receptors in cerebral vasculature. Its mechanism in cluster headache involves reducing neurogenic inflammation, constricting dilated cerebral blood vessels, and interrupting pain signaling pathways. DHE effectively aborts acute cluster headache attacks by modulating neurovascular tone and reducing pain transmission.