Monosodium glutamate (MSG) avoidance in cluster headache management is based on its potential role as a neurogenic trigger through glutamate receptor activation and neurotransmitter modulation. By reducing dietary glutamate intake, patients may experience decreased neuronal excitability and inflammatory responses that could potentially precipitate or exacerbate cluster headache episodes. The mechanism suggests that glutamate receptor antagonism may help mitigate neurogenic pain signaling and reduce headache frequency or intensity.