Methylsulfonylmethane (MSM) may potentially modulate inflammatory pathways and oxidative stress in cluster headache management, though its precise mechanism is not fully elucidated. As a sulfur-containing compound, MSM appears to reduce neurogenic inflammation and may provide analgesic effects by modulating pain signaling and supporting cellular membrane integrity. Limited clinical evidence suggests it could offer supportive relief in cluster headache management, primarily through its anti-inflammatory and antioxidant properties.