Multivitamins in Cluster Headache management are primarily used to support neurological function and potentially reduce oxidative stress, with riboflavin (Vitamin B2) and other B-complex vitamins potentially modulating mitochondrial energy metabolism and neurotransmitter synthesis. While not a primary treatment, some studies suggest that specific vitamin combinations may help reduce headache frequency and intensity by improving neuronal resilience and supporting metabolic processes involved in pain regulation.